Publications

Dr. Benjamin Levi and his laboratory have produced prolific works. Major media have comprised of scientific journals such as Journal of Plastic Reconstructive Surgery, Public Library of Science, Science of Translational Medicine, Developmental Biology, Proceedings of the National Academy of Science, and Journal of Biological Chemistry.

Levi, B. Catalyst for My Career in Burn and Trauma Research and Clinical Care: A Decade After the Jacobson Promising Investigator Award. J Am Coll Surg. 2024; :. doi: 10.1097/XCS.0000000000001243. PubMed PMID:39530505 .
Zhu, M, Yea, JH, Li, Z, Qin, Q, Xu, M, Xing, X, Negri, S, Archer, M, Mittal, M, Levi, B, James, AW. Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification. Bone Res. 2024;12 (1):54. doi: 10.1038/s41413-024-00358-0. PubMed PMID:39327413 PubMed Central PMC11427465.
Nunez, J, Mironov, S, Wan, B, Hazime, A, Clark, A, Akarichi, C, Korlakunta, S, Mandell, S, Arnoldo, B, Chan, R, Goverman, J, Huebinger, R, Park, C, Evers, B, Carlson, D, Berenfeld, O, Levi, B. Novel multi-spectral short-wave infrared imaging for assessment of human burn wound depth. Wound Repair Regen. 2024; :. doi: 10.1111/wrr.13221. PubMed PMID:39323286 .
Omotoye, S, Singleton, MJ, Zagrodzky, J, Clark, B, Sharma, D, Metzl, MD, Gallagher, MM, Meininghaus, DG, Leung, L, Garg, J, Warrier, N, Panico, A, Tamirisa, K, Sanchez, J, Mickelsen, S, Sardana, M, Shah, D, Athill, C, Hayat, J, Silva, R, Clark, AT, Gray, M, Levi, B, Kulstad, E, Girouard, S et al.. Mechanisms of action behind the protective effects of proactive esophageal cooling during radiofrequency catheter ablation in the left atrium. Heart Rhythm O2. 2024;5 (6):403-416. doi: 10.1016/j.hroo.2024.05.002. PubMed PMID:38984358 PubMed Central PMC11228283.
Qin, Q, Ramesh, S, Li, Z, Zhong, L, Cherief, M, Archer, M, Xing, X, Thottappillil, N, Gomez-Salazar, M, Xu, M, Zhu, M, Chang, L, Uniyal, A, Mazhar, K, Mittal, M, McCarthy, EF, Morris, CD, Levi, B, Guan, Y, Clemens, TL, Price, TJ, James, AW. TrkA ⁺ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression. bioRxiv. 2024; :. doi: 10.1101/2024.06.20.599869. PubMed PMID:38979210 PubMed Central PMC11230162.
Xu, M, Zhu, M, Qin, Q, Xing, X, Archer, M, Ramesh, S, Cherief, M, Li, Z, Levi, B, Clemens, TL, James, AW. Neuronal regulation of bone and tendon injury repair: a focused review. J Bone Miner Res. 2024;39 (8):1045-1060. doi: 10.1093/jbmr/zjae087. PubMed PMID:38836494 .
Hsieh, ML, Choi, JH, Korlakunta, S, Zhang, Y, Levi, B. Elucidating the Mechanism of Radiation Therapy on Mesenchymal Cell Fate in Preventing Heterotopic Ossification. Ann Surg. 2024; :. doi: 10.1097/SLA.0000000000006366. PubMed PMID:38829115 .
Vishlaghi, N, Guo, L, Griswold-Wheeler, D, Sun, Y, Booker, C, Crossley, JL, Bancroft, AC, Juan, C, Korlakunta, S, Ramesh, S, Pagani, CA, Xu, L, James, AW, Tower, RJ, Dellinger, M, Levi, B. Vegfc-expressing cells form heterotopic bone after musculoskeletal injury. Cell Rep. 2024;43 (4):114049. doi: 10.1016/j.celrep.2024.114049. PubMed PMID:38573853 .
Juan, C, Bancroft, AC, Choi, JH, Nunez, JH, Pagani, CA, Lin, YS, Hsiao, EC, Levi, B. Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification. Biomolecules. 2024;14 (3):. doi: 10.3390/biom14030349. PubMed PMID:38540768 PubMed Central PMC10968060.
Kang, H, Strong, AL, Sun, Y, Guo, L, Juan, C, Bancroft, AC, Choi, JH, Pagani, CA, Fernandes, AA, Woodard, M, Lee, J, Ramesh, S, James, AW, Hudson, D, Dalby, KN, Xu, L, Tower, RJ, Levi, B. The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair. Bone Res. 2024;12 (1):17. doi: 10.1038/s41413-024-00320-0. PubMed PMID:38472175 PubMed Central PMC10933265.
DeLuca, JP, Selig, DJ, Vir, P, Vuong, CV, Della-Volpe, J, Rivera, IM, Park, C, Levi, B, Pratt, KP, Stewart, IJ. Seraph 100 Microbind Affinity Blood Filter Does Not Clear Antibiotics: An Analysis of Antibiotic Concentration Data from PURIFY-OBS. Blood Purif. 2024;53 (5):379-385. doi: 10.1159/000531951. PubMed PMID:38219716 .
Cherief, M, Xu, J, Li, Z, Tower, RJ, Ramesh, S, Qin, Q, Gomez-Salazar, M, Yea, JH, Lee, S, Negri, S, Xu, M, Price, T, Kendal, AR, Fan, CM, Clemens, TL, Levi, B, James, AW. TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair. Sci Transl Med. 2023;15 (727):eade4619. doi: 10.1126/scitranslmed.ade4619. PubMed PMID:38117901 .
Bhat, SG, Nagaraj, M, Balentine, C, Hogan, T, Meier, J, Prince, H, Abdelfattah, K, Zeh, H, Levi, B. Assessing a Structured Mental Fitness Program for Academic Acute Care Surgeons: A Pilot Study. J Surg Res. 2024;295 :9-18. doi: 10.1016/j.jss.2023.09.052. PubMed PMID:37956507 .
Xiao, X, Juan, C, Drennon, T, Uytingco, CR, Vishlaghi, N, Sokolowskei, D, Xu, L, Levi, B, Sammarco, MC, Tower, RJ. Spatial transcriptomic interrogation of the murine bone marrow signaling landscape. Bone Res. 2023;11 (1):59. doi: 10.1038/s41413-023-00298-1. PubMed PMID:37926705 PubMed Central PMC10625929.
Crossley, JL, Ostashevskaya-Gohstand, S, Comazzetto, S, Hook, JS, Guo, L, Vishlaghi, N, Juan, C, Xu, L, Horswill, AR, Hoxhaj, G, Moreland, JG, Tower, RJ, Levi, B. Itaconate-producing neutrophils regulate local and systemic inflammation following trauma. JCI Insight. 2023;8 (20):. doi: 10.1172/jci.insight.169208. PubMed PMID:37707952 PubMed Central PMC10619500.
Henn, D, Zhao, D, Sivaraj, D, Trotsyuk, A, Bonham, CA, Fischer, KS, Kehl, T, Fehlmann, T, Greco, AH, Kussie, HC, Moortgat Illouz, SE, Padmanabhan, J, Barrera, JA, Kneser, U, Lenhof, HP, Januszyk, M, Levi, B, Keller, A, Longaker, MT, Chen, K, Qi, LS, Gurtner, GC. Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healing. Nat Commun. 2023;14 (1):4729. doi: 10.1038/s41467-023-40519-z. PubMed PMID:37550295 PubMed Central PMC10406832.
Yea, JH, Gomez-Salazar, M, Onggo, S, Li, Z, Thottappillil, N, Cherief, M, Negri, S, Xing, X, Qin, Q, Tower, RJ, Fan, CM, Levi, B, James, AW. Tppp3⁺ synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma. Bone Res. 2023;11 (1):39. doi: 10.1038/s41413-023-00272-x. PubMed PMID:37479686 PubMed Central PMC10361999.
Nunez, JH, Juan, C, Sun, Y, Hong, J, Bancroft, AC, Hwang, C, Medrano, JM, Huber, AK, Tower, RJ, Levi, B. Neutrophil and NETosis Modulation in Traumatic Heterotopic Ossification. Ann Surg. 2023;278 (6):e1289-e1298. doi: 10.1097/SLA.0000000000005940. PubMed PMID:37325925 PubMed Central PMC10724380.
Loder, S, Patel, N, Morgani, S, Sambon, M, Leucht, P, Levi, B. Genetic models for lineage tracing in musculoskeletal development, injury, and healing. Bone. 2023;173 :116777. doi: 10.1016/j.bone.2023.116777. PubMed PMID:37156345 PubMed Central PMC10860167.
Lin, YH, Zeng, Q, Jia, Y, Wang, Z, Li, L, Hsieh, MH, Cheng, Q, Pagani, CA, Livingston, N, Lee, J, Zhang, Y, Sharma, T, Siegwart, DJ, Yimlamai, D, Levi, B, Zhu, H. In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration. Hepatology. 2023;78 (4):1133-1148. doi: 10.1097/HEP.0000000000000402. PubMed PMID:37039560 PubMed Central PMC10524179.
Rowe, CJ, Walsh, SA, Dragon, AH, Rhodes, AM, Pak, OL, Ronzier, E, Levi, B, Potter, BK, Spreadborough, PJ, Davis, TA. Tourniquet-induced ischemia creates increased risk of organ dysfunction and mortality following delayed limb amputation. Injury. 2023; :. doi: 10.1016/j.injury.2023.02.047. PubMed PMID:36906480 .
Mohamed, FF, Ge, C, Hallett, SA, Bancroft, AC, Cowling, RT, Ono, N, Binrayes, AA, Greenberg, B, Levi, B, Kaartinen, VM, Franceschi, RT. Control of craniofacial development by the collagen receptor, discoidin domain receptor 2. Elife. 2023;12 :. doi: 10.7554/eLife.77257. PubMed PMID:36656123 PubMed Central PMC9977278.
Pagani, CA, Bancroft, AC, Tower, RJ, Livingston, N, Sun, Y, Hong, JY, Kent, RN 3rd, Strong, AL, Nunez, JH, Medrano, JMR, Patel, N, Nanes, BA, Dean, KM, Li, Z, Ge, C, Baker, BM, James, AW, Weiss, SJ, Franceschi, RT, Levi, B. Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization. Sci Adv. 2022;8 (51):eabq6152. doi: 10.1126/sciadv.abq6152. PubMed PMID:36542719 PubMed Central PMC9770942.
Qin, Q, Lee, S, Patel, N, Walden, K, Gomez-Salazar, M, Levi, B, James, AW. Neurovascular coupling in bone regeneration. Exp Mol Med. 2022;54 (11):1844-1849. doi: 10.1038/s12276-022-00899-6. PubMed PMID:36446849 PubMed Central PMC9722927.
Cherief, M, Negri, S, Qin, Q, Pagani, CA, Lee, S, Yang, YP, Clemens, TL, Levi, B, James, AW. TrkA+ Neurons Induce Pathologic Regeneration After Soft Tissue Trauma. Stem Cells Transl Med. 2022;11 (11):1165-1176. doi: 10.1093/stcltm/szac073. PubMed PMID:36222619 PubMed Central PMC9672853.
Tower, RJ, Bancroft, AC, Chowdary, AR, Barnes, S, Edwards, NJ, Pagani, CA, Dawson, LA, Levi, B. Single-cell mapping of regenerative and fibrotic healing responses after musculoskeletal injury. Stem Cell Reports. 2022;17 (10):2334-2348. doi: 10.1016/j.stemcr.2022.08.011. PubMed PMID:36150381 PubMed Central PMC9561541.
Audu, CO, Melvin, WJ, Joshi, AD, Wolf, SJ, Moon, JY, Davis, FM, Barrett, EC, Mangum, KD, Deng, H, Xing, X, Wasikowski, R, Tsoi, LC, Sharma, SB, Bauer, TM, Shadiow, J, Corriere, MA, Obi, AT, Kunkel, SL, Levi, B, Moore, BB, Gudjonsson, JE, Smith, AM, Gallagher, KA. Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair. Cell Mol Immunol. 2022;19 (11):1251-1262. doi: 10.1038/s41423-022-00919-5. PubMed PMID:36127466 PubMed Central PMC9622909.
Spreadborough, PJ, Strong, AL, Mares, J, Levi, B, Davis, TA. Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation. J Orthop Surg Res. 2022;17 (1):422. doi: 10.1186/s13018-022-03321-z. PubMed PMID:36123728 PubMed Central PMC9484189.
Chowdary, AR, Maerz, T, Henn, D, Hankenson, KD, Pagani, CA, Marini, S, Gallagher, K, Aguilar, CA, Tower, RJ, Levi, B. Macrophage-mediated PDGF Activation Correlates With Regenerative Outcomes Following Musculoskeletal Trauma. Ann Surg. 2023;278 (2):e349-e359. doi: 10.1097/SLA.0000000000005704. PubMed PMID:36111847 PubMed Central PMC10014496.
Patel, NK, Nunez, JH, Sorkin, M, Marini, S, Pagani, CA, Strong, AL, Hwang, CD, Li, S, Padmanabhan, KR, Kumar, R, Bancroft, AC, Greenstein, JA, Nelson, R, Rasheed, HA, Livingston, N, Vasquez, K, Huber, AK, Levi, B. Macrophage TGF-β signaling is critical for wound healing with heterotopic ossification after trauma. JCI Insight. 2022;7 (20):. doi: 10.1172/jci.insight.144925. PubMed PMID:36099022 PubMed Central PMC9714796.
Nunez, JH, Strong, AL, Comish, P, Hespe, GE, Harvey, J, Sorkin, M, Levi, B. A Review of Laser Therapies for the Treatment of Scarring and Vascular Anomalies. Adv Wound Care (New Rochelle). 2023;12 (2):68-84. doi: 10.1089/wound.2021.0045. PubMed PMID:35951024 .
Hwang, CD, Pagani, CA, Nunez, JH, Cherief, M, Qin, Q, Gomez-Salazar, M, Kadaikal, B, Kang, H, Chowdary, AR, Patel, N, James, AW, Levi, B. Contemporary perspectives on heterotopic ossification. JCI Insight. 2022;7 (14):. doi: 10.1172/jci.insight.158996. PubMed PMID:35866484 PubMed Central PMC9431693.
Negri, S, Wang, Y, Li, Z, Qin, Q, Lee, S, Cherief, M, Xu, J, Hsu, GC, Tower, RJ, Presson, B, Levin, A, McCarthy, E, Levi, B, James, AW. Acetabular Reaming Is a Reliable Model to Produce and Characterize Periarticular Heterotopic Ossification of the Hip. Stem Cells Transl Med. 2022;11 (8):876-888. doi: 10.1093/stcltm/szac042. PubMed PMID:35758541 PubMed Central PMC9397657.
Qin, Q, Gomez-Salazar, M, Cherief, M, Pagani, CA, Lee, S, Hwang, C, Tower, RJ, Onggo, S, Sun, Y, Piplani, A, Li, Z, Ramesh, S, Clemens, TL, Levi, B, James, AW. Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma. Bone Res. 2022;10 (1):43. doi: 10.1038/s41413-022-00216-x. PubMed PMID:35641477 PubMed Central PMC9156761.
Park, C, Cho, Y, Harvey, J, Arnoldo, B, Levi, B. Telehealth and Burn Care: From Faxes to Augmented Reality. Bioengineering (Basel). 2022;9 (5):. doi: 10.3390/bioengineering9050211. PubMed PMID:35621489 PubMed Central PMC9137829.
Chitty, SA, Mobbs, S, Rifkin, BS, Stogner, SW, Lewis, MS, Betancourt, J, DellaVolpe, J, Abouzahr, F, Wilhelm, AM, Szerlip, HM, Parikh, A, Gaeta, RM, Rivera, I, Park, C, Levi, B, Anesi, GL, Alcover, KC, Arnold, TB, Howard, JT, Sharma, K, Pratt, KP, Stewart, IJ, Chung, KK. A Multicenter Evaluation of the Seraph 100 Microbind Affinity Blood Filter for the Treatment of Severe COVID-19. Crit Care Explor. 2022;4 (4):e0662. doi: 10.1097/CCE.0000000000000662. PubMed PMID:35506015 PubMed Central PMC9049035.
Lee, S, Hwang, C, Marini, S, Tower, RJ, Qin, Q, Negri, S, Pagani, CA, Sun, Y, Stepien, DM, Sorkin, M, Kubiak, CA, Visser, ND, Meyers, CA, Wang, Y, Rasheed, HA, Xu, J, Miller, S, Huber, AK, Minichiello, L, Cederna, PS, Kemp, SWP, Clemens, TL, James, AW, Levi, B. NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma. Nat Commun. 2021;12 (1):4939. doi: 10.1038/s41467-021-25143-z. PubMed PMID:34400627 PubMed Central PMC8368242.
Gupta, VS, Meier, J, Nunez, JH, Abdelfattah, KR, Balentine, C, Zeh, HJ, Carlson, D, Levi, B. How We Did It: Implementing a Trainee-Focused Surgical Research Curriculum and Infrastructure. J Surg Educ. 2022;79 (1):35-39. doi: 10.1016/j.jsurg.2021.07.010. PubMed PMID:34353762 .
Larouche, JA, Mohiuddin, M, Choi, JJ, Ulintz, PJ, Fraczek, P, Sabin, K, Pitchiaya, S, Kurpiers, SJ, Castor-Macias, J, Liu, W, Hastings, RL, Brown, LA, Markworth, JF, De Silva, K, Levi, B, Merajver, SD, Valdez, G, Chakkalakal, JV, Jang, YC, Brooks, SV, Aguilar, CA. Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging. Elife. 2021;10 :. doi: 10.7554/eLife.66749. PubMed PMID:34323217 PubMed Central PMC8360658.
Dolgachev, VA, Ciotti, S, Liechty, E, Levi, B, Wang, SC, Baker, JR, Hemmila, MR. Dermal Nanoemulsion Treatment Reduces Burn Wound Conversion and Improves Skin Healing in a Porcine Model of Thermal Burn Injury. J Burn Care Res. 2021;42 (6):1232-1242. doi: 10.1093/jbcr/irab118. PubMed PMID:34145458 PubMed Central PMC8633125.
van de Vyver, M, Boodhoo, K, Frazier, T, Hamel, K, Kopcewicz, M, Levi, B, Maartens, M, Machcinska, S, Nunez, J, Pagani, C, Rogers, E, Walendzik, K, Wisniewska, J, Gawronska-Kozak, B, Gimble, JM. Histology Scoring System for Murine Cutaneous Wounds. Stem Cells Dev. 2021;30 (23):1141-1152. doi: 10.1089/scd.2021.0124. PubMed PMID:34130483 PubMed Central PMC9022171.
Edwards, NJ, Hobson, E, Dey, D, Rhodes, A, Overmann, A, Hoyt, B, Walsh, SA, Pagani, CA, Strong, AL, Hespe, GE, Padmanabhan, KR, Huber, A, Deng, C, Davis, TA, Levi, B. High Frequency Spectral Ultrasound Imaging Detects Early Heterotopic Ossification in Rodents. Stem Cells Dev. 2021;30 (9):473-484. doi: 10.1089/scd.2021.0011. PubMed PMID:33715398 PubMed Central PMC8106252.
Pagani, CA, Huber, AK, Hwang, C, Marini, S, Padmanabhan, K, Livingston, N, Nunez, J, Sun, Y, Edwards, N, Cheng, YH, Visser, N, Yu, P, Patel, N, Greenstein, JA, Rasheed, H, Nelson, R, Kessel, K, Vasquez, K, Strong, AL, Hespe, GE, Song, JY, Wellik, DM, Levi, B. Novel Lineage-Tracing System to Identify Site-Specific Ectopic Bone Precursor Cells. Stem Cell Reports. 2021;16 (3):626-640. doi: 10.1016/j.stemcr.2021.01.011. PubMed PMID:33606989 PubMed Central PMC7940250.
Bredbeck, BC, Maguire, LH, Alam, HB, Bednar, F, Delano, MJ, Dimick, JB, Ignatoski, KMW, Di Magliano, MP, Levi, B. Teamwork at the Bench: Strategies for Collaborative Surgical Science in a Pandemic. J Surg Res. 2021;261 :39-42. doi: 10.1016/j.jss.2020.12.002. PubMed PMID:33412507 PubMed Central PMC8026522.
Strong, AL, Spreadborough, PJ, Dey, D, Yang, P, Li, S, Lee, A, Haskins, RM, Grimm, PD, Kumar, R, Bradley, MJ, Yu, PB, Levi, B, Davis, TA. BMP Ligand Trap ALK3-Fc Attenuates Osteogenesis and Heterotopic Ossification in Blast-Related Lower Extremity Trauma. Stem Cells Dev. 2021;30 (2):91-105. doi: 10.1089/scd.2020.0162. PubMed PMID:33256557 PubMed Central PMC7826435.
Edwards, NJ, Hwang, C, Marini, S, Pagani, CA, Spreadborough, PJ, Rowe, CJ, Yu, P, Mei, A, Visser, N, Li, S, Hespe, GE, Huber, AK, Strong, AL, Shelef, MA, Knight, JS, Davis, TA, Levi, B. The role of neutrophil extracellular traps and TLR signaling in skeletal muscle ischemia reperfusion injury. FASEB J. 2020;34 (12):15753-15770. doi: 10.1096/fj.202000994RR. PubMed PMID:33089917 PubMed Central PMC8054227.
Salhotra, A, Shah, HN, Levi, B, Longaker, MT. Mechanisms of bone development and repair. Nat Rev Mol Cell Biol. 2020;21 (11):696-711. doi: 10.1038/s41580-020-00279-w. PubMed PMID:32901139 PubMed Central PMC7699981.
Murphy, MP, Koepke, LS, Lopez, MT, Tong, X, Ambrosi, TH, Gulati, GS, Marecic, O, Wang, Y, Ransom, RC, Hoover, MY, Steininger, H, Zhao, L, Walkiewicz, MP, Quarto, N, Levi, B, Wan, DC, Weissman, IL, Goodman, SB, Yang, F, Longaker, MT, Chan, CKF. Articular cartilage regeneration by activated skeletal stem cells. Nat Med. 2020;26 (10):1583-1592. doi: 10.1038/s41591-020-1013-2. PubMed PMID:32807933 PubMed Central PMC7704061.
Huber, AK, Patel, N, Pagani, CA, Marini, S, Padmanabhan, KR, Matera, DL, Said, M, Hwang, C, Hsu, GC, Poli, AA, Strong, AL, Visser, ND, Greenstein, JA, Nelson, R, Li, S, Longaker, MT, Tang, Y, Weiss, SJ, Baker, BM, James, AW, Levi, B. Immobilization after injury alters extracellular matrix and stem cell fate. J Clin Invest. 2020;130 (10):5444-5460. doi: 10.1172/JCI136142. PubMed PMID:32673290 PubMed Central PMC7524473.
Strong, AL, Spreadborough, PJ, Pagani, CA, Haskins, RM, Dey, D, Grimm, PD, Kaneko, K, Marini, S, Huber, AK, Hwang, C, Westover, K, Mishina, Y, Bradley, MJ, Levi, B, Davis, TA. Small molecule inhibition of non-canonical (TAK1-mediated) BMP signaling results in reduced chondrogenic ossification and heterotopic ossification in a rat model of blast-associated combat-related lower limb trauma. Bone. 2020;139 :115517. doi: 10.1016/j.bone.2020.115517. PubMed PMID:32622875 PubMed Central PMC7945876.
Hwang, C, Pagani, CA, Das, N, Marini, S, Huber, AK, Xie, L, Jimenez, J, Brydges, S, Lim, WK, Nannuru, KC, Murphy, AJ, Economides, AN, Hatsell, SJ, Levi, B. Activin A does not drive post-traumatic heterotopic ossification. Bone. 2020;138 :115473. doi: 10.1016/j.bone.2020.115473. PubMed PMID:32553795 .
Sono, T, Hsu, CY, Wang, Y, Xu, J, Cherief, M, Marini, S, Huber, AK, Miller, S, Péault, B, Levi, B, James, AW. Perivascular Fibro-Adipogenic Progenitor Tracing during Post-Traumatic Osteoarthritis. Am J Pathol. 2020;190 (9):1909-1920. doi: 10.1016/j.ajpath.2020.05.017. PubMed PMID:32533926 PubMed Central PMC7456743.
Hsu, GC, Marini, S, Negri, S, Wang, Y, Xu, J, Pagani, C, Hwang, C, Stepien, D, Meyers, CA, Miller, S, McCarthy, E, Lyons, KM, Levi, B, James, AW. Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification. JCI Insight. 2020;5 (13):. doi: 10.1172/jci.insight.135432. PubMed PMID:32484792 PubMed Central PMC7406255.
Strong, AL, Levi, B. Discussion: Docosahexaenoic Acid Improves Diabetic Wound Healing in a Rat Model by Restoring Impaired Plasticity of Macrophage Progenitor Cells. Plast Reconstr Surg. 2020;145 (5):951e-952e. doi: 10.1097/PRS.0000000000006797. PubMed PMID:32332537 .
Stepien, DM, Hwang, C, Marini, S, Pagani, CA, Sorkin, M, Visser, ND, Huber, AK, Edwards, NJ, Loder, SJ, Vasquez, K, Aguilar, CA, Kumar, R, Mascharak, S, Longaker, MT, Li, J, Levi, B. Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis. J Immunol. 2020;204 (8):2203-2215. doi: 10.4049/jimmunol.1900814. PubMed PMID:32161098 PubMed Central PMC8080967.
Pignolo, RJ, Cheung, K, Kile, S, Fitzpatrick, MA, De Cunto, C, Al Mukaddam, M, Hsiao, EC, Baujat, G, Delai, P, Eekhoff, EMW, Di Rocco, M, Grunwald, Z, Haga, N, Keen, R, Levi, B, Morhart, R, Scott, C, Sherman, A, Zhang, K, Kaplan, FS. Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association Global Registry. Bone. 2020;134 :115274. doi: 10.1016/j.bone.2020.115274. PubMed PMID:32062004 .
Sorkin, M, Huber, AK, Hwang, C, Carson, WF 4th, Menon, R, Li, J, Vasquez, K, Pagani, C, Patel, N, Li, S, Visser, ND, Niknafs, Y, Loder, S, Scola, M, Nycz, D, Gallagher, K, McCauley, LK, Xu, J, James, AW, Agarwal, S, Kunkel, S, Mishina, Y, Levi, B. Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nat Commun. 2020;11 (1):722. doi: 10.1038/s41467-019-14172-4. PubMed PMID:32024825 PubMed Central PMC7002453.
Hwang, C, Marini, S, Huber, AK, Stepien, DM, Sorkin, M, Loder, S, Pagani, CA, Li, J, Visser, ND, Vasquez, K, Garada, MA, Li, S, Xu, J, Hsu, CY, Yu, PB, James, AW, Mishina, Y, Agarwal, S, Li, J, Levi, B. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019;7 :36. doi: 10.1038/s41413-019-0075-6. PubMed PMID:31840004 PubMed Central PMC6904752.
Kaji, DA, Tan, Z, Johnson, GL, Huang, W, Vasquez, K, Lehoczky, JA, Levi, B, Cheah, KSE, Huang, AH. Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease. J Orthop Res. 2020;38 (4):708-718. doi: 10.1002/jor.24523. PubMed PMID:31721278 PubMed Central PMC7213644.
Agarwal, S, Loder, SJ, Cholok, D, Li, J, Bian, G, Yalavarthi, S, Li, S, Carson, WF, Hwang, C, Marini, S, Pagani, C, Edwards, N, Delano, MJ, Standiford, TJ, Knight, JS, Kunkel, SL, Mishina, Y, Ward, PA, Levi, B. Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation. Front Immunol. 2019;10 :2148. doi: 10.3389/fimmu.2019.02148. PubMed PMID:31708911 PubMed Central PMC6821718.
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Meyers, C, Lisiecki, J, Miller, S, Levin, A, Fayad, L, Ding, C, Sono, T, McCarthy, E, Levi, B, James, AW. Heterotopic Ossification: A Comprehensive Review. JBMR Plus. 2019;3 (4):e10172. doi: 10.1002/jbm4.10172. PubMed PMID:31044187 PubMed Central PMC6478587.
Annamalai, RT, Hong, X, Schott, NG, Tiruchinapally, G, Levi, B, Stegemann, JP. Injectable osteogenic microtissues containing mesenchymal stromal cells conformally fill and repair critical-size defects. Biomaterials. 2019;208 :32-44. doi: 10.1016/j.biomaterials.2019.04.001. PubMed PMID:30991216 PubMed Central PMC6500486.
Merceron, C, Ranganathan, K, Wang, E, Tata, Z, Makkapati, S, Khan, MP, Mangiavini, L, Yao, AQ, Castellini, L, Levi, B, Giaccia, AJ, Schipani, E. Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual. Bone Res. 2019;7 :7. doi: 10.1038/s41413-019-0045-z. PubMed PMID:30792937 PubMed Central PMC6382776.
Hsieh, HHS, Agarwal, S, Cholok, DJ, Loder, SJ, Kaneko, K, Huber, A, Chung, MT, Ranganathan, K, Habbouche, J, Li, J, Butts, J, Reimer, J, Kaura, A, Drake, J, Breuler, C, Priest, CR, Nguyen, J, Brownley, C, Peterson, J, Ozgurel, SU, Niknafs, YS, Li, S, Inagaki, M, Scott, G, Krebsbach, PH et al.. Coordinating Tissue Regeneration Through Transforming Growth Factor-β Activated Kinase 1 Inactivation and Reactivation. Stem Cells. 2019;37 (6):766-778. doi: 10.1002/stem.2991. PubMed PMID:30786091 PubMed Central PMC6542699.
Kubiak, CA, Ranganathan, K, Matusko, N, Jacobson, JA, Wang, SC, Park, PK, Levi, BL. Computed Tomography Evidence of Psoas Muscle Atrophy Without Concomitant Tendon Wasting in Early Sepsis. J Surg Res. 2019;234 :210-216. doi: 10.1016/j.jss.2018.09.010. PubMed PMID:30527476 PubMed Central PMC6481648.
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Strong, AL, Levi, B. Discussion: Deferoxamine Preconditioning of Irradiated Tissue Improves Perfusion and Fat Graft Retention. Plast Reconstr Surg. 2018;141 (3):666-667. doi: 10.1097/PRS.0000000000004186. PubMed PMID:29481397 .
Annamalai, RT, Turner, PA, Carson, WF 4th, Levi, B, Kunkel, S, Stegemann, JP. Harnessing macrophage-mediated degradation of gelatin microspheres for spatiotemporal control of BMP2 release. Biomaterials. 2018;161 :216-227. doi: 10.1016/j.biomaterials.2018.01.040. PubMed PMID:29421557 PubMed Central PMC5831261.
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Qureshi, AT, Dey, D, Sanders, EM, Seavey, JG, Tomasino, AM, Moss, K, Wheatley, B, Cholok, D, Loder, S, Li, J, Levi, B, Davis, TA. Inhibition of Mammalian Target of Rapamycin Signaling with Rapamycin Prevents Trauma-Induced Heterotopic Ossification. Am J Pathol. 2017;187 (11):2536-2545. doi: 10.1016/j.ajpath.2017.07.010. PubMed PMID:29029772 PubMed Central PMC5809339.
Cholok, D, Chung, MT, Ranganathan, K, Ucer, S, Day, D, Davis, TA, Mishina, Y, Levi, B. Heterotopic ossification and the elucidation of pathologic differentiation. Bone. 2018;109 :12-21. doi: 10.1016/j.bone.2017.09.019. PubMed PMID:28987285 PubMed Central PMC6585944.
Strong, AL, Agarwal, S, Cederna, PS, Levi, B. Peripheral Neuropathy and Nerve Compression Syndromes in Burns. Clin Plast Surg. 2017;44 (4):793-803. doi: 10.1016/j.cps.2017.05.010. PubMed PMID:28888304 PubMed Central PMC5674779.
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Dey, D, Wheatley, BM, Cholok, D, Agarwal, S, Yu, PB, Levi, B, Davis, TA. The traumatic bone: trauma-induced heterotopic ossification. Transl Res. 2017;186 :95-111. doi: 10.1016/j.trsl.2017.06.004. PubMed PMID:28668522 PubMed Central PMC6715128.
Levi, B. "AMP"(K)ed up recovery from ischemia-reperfusion injury. Sci Transl Med. 2017;9 (395):. doi: 10.1126/scitranslmed.aan6194. PubMed PMID:28637927 .
Friedstat, J, Brown, DA, Levi, B. Chemical, Electrical, and Radiation Injuries. Clin Plast Surg. 2017;44 (3):657-669. doi: 10.1016/j.cps.2017.02.021. PubMed PMID:28576255 PubMed Central PMC5488710.
Strong, AL, Neumeister, MW, Levi, B. Stem Cells and Tissue Engineering: Regeneration of the Skin and Its Contents. Clin Plast Surg. 2017;44 (3):635-650. doi: 10.1016/j.cps.2017.02.020. PubMed PMID:28576253 PubMed Central PMC5513194.
Griggs, C, Goverman, J, Bittner, EA, Levi, B. Sedation and Pain Management in Burn Patients. Clin Plast Surg. 2017;44 (3):535-540. doi: 10.1016/j.cps.2017.02.026. PubMed PMID:28576242 PubMed Central PMC5642992.
Sorkin, M, Agarwal, S, Ranganathan, K, Loder, S, Cholok, D, Fireman, D, Li, J, Li, S, Zhao, B, Mishina, Y, Cederna, P, Levi, B. Hair follicle specific ACVR1/ALK2 critically affects skin morphogenesis and attenuates wound healing. Wound Repair Regen. 2017;25 (3):521-525. doi: 10.1111/wrr.12549. PubMed PMID:28513105 PubMed Central PMC5568946.
Grafe, I, Alexander, S, Peterson, JR, Snider, TN, Levi, B, Lee, B, Mishina, Y. TGF-β Family Signaling in Mesenchymal Differentiation. Cold Spring Harb Perspect Biol. 2018;10 (5):. doi: 10.1101/cshperspect.a022202. PubMed PMID:28507020 PubMed Central PMC5932590.
Levi, B. "TrkA"cking why "no pain, no gain" is the rule for bone formation. Sci Transl Med. 2017;9 (389):. doi: 10.1126/scitranslmed.aan3780. PubMed PMID:28490668 .
Sung Hsieh, HH, Chung, MT, Allen, RM, Ranganathan, K, Habbouche, J, Cholok, D, Butts, J, Kaura, A, Tiruvannamalai-Annamalai, R, Breuler, C, Priest, C, Loder, SJ, Li, J, Li, S, Stegemann, J, Kunkel, SL, Levi, B. Evaluation of Salivary Cytokines for Diagnosis of both Trauma-Induced and Genetic Heterotopic Ossification. Front Endocrinol (Lausanne). 2017;8 :74. doi: 10.3389/fendo.2017.00074. PubMed PMID:28484423 PubMed Central PMC5401868.
Levi, B, Ricci, JA, Donelan, MB. Vermillion Reconstruction With Anal Verge Transitional Epithelium: Turning Things Upside Down. J Burn Care Res. 2018;39 (2):218-223. doi: 10.1097/BCR.0000000000000569. PubMed PMID:28481757 .
Nguyen, V, Meyers, CA, Yan, N, Agarwal, S, Levi, B, James, AW. BMP-2-induced bone formation and neural inflammation. J Orthop. 2017;14 (2):252-256. doi: 10.1016/j.jor.2017.03.003. PubMed PMID:28367006 PubMed Central PMC5362134.
Ko, JH, Levi, B. Optimizing the Treatment of Burn Injuries of the Upper Extremity. Hand Clin. 2017;33 (2):xiii. doi: 10.1016/j.hcl.2017.02.001. PubMed PMID:28363305 .
Agarwal, S, Loder, S, Levi, B. Heterotopic Ossification Following Upper Extremity Injury. Hand Clin. 2017;33 (2):363-373. doi: 10.1016/j.hcl.2016.12.013. PubMed PMID:28363301 PubMed Central PMC5394800.
Sorkin, M, Cholok, D, Levi, B. Scar Management of the Burned Hand. Hand Clin. 2017;33 (2):305-315. doi: 10.1016/j.hcl.2016.12.009. PubMed PMID:28363297 PubMed Central PMC5436973.
Levi, B. Macrophages take rheumatoid arthritis up a "Notch". Sci Transl Med. 2017;9 (383):. doi: 10.1126/scitranslmed.aan3022. PubMed PMID:28356509 .
Cocks, M, Mohan, A, Meyers, CA, Ding, C, Levi, B, McCarthy, E, James, AW. Vascular patterning in human heterotopic ossification. Hum Pathol. 2017;63 :165-170. doi: 10.1016/j.humpath.2017.03.005. PubMed PMID:28315426 PubMed Central PMC5529164.
Agarwal, S, Loder, S, Cholok, D, Li, J, Breuler, C, Drake, J, Brownley, C, Peterson, J, Li, S, Levi, B. Surgical Excision of Heterotopic Ossification Leads to Re-Emergence of Mesenchymal Stem Cell Populations Responsible for Recurrence. Stem Cells Transl Med. 2017;6 (3):799-806. doi: 10.5966/sctm.2015-0365. PubMed PMID:28297577 PubMed Central PMC5442786.
Rinkinen, J, Levi, B, Cederna, PS. Discussion: Homeotic and Embryonic Gene Expression in Breast Adipose Tissue and in Adipose Tissues Used as Donor Sites in Plastic Surgery. Plast Reconstr Surg. 2017;139 (3):693e-694e. doi: 10.1097/PRS.0000000000003071. PubMed PMID:28234839 .
Agarwal, S, Lloyd, WR, Loder, SJ, Chung, MT, Hwang, C, Morris, MD, Levi, B. Combined reflectance and Raman spectroscopy to assess degree of in vivo angiogenesis after tissue injury. J Surg Res. 2017;209 :174-177. doi: 10.1016/j.jss.2016.09.017. PubMed PMID:28032556 PubMed Central PMC5536340.
Agarwal, S, Cholok, D, Loder, S, Li, J, Breuler, C, Chung, MT, Sung, HH, Ranganathan, K, Habbouche, J, Drake, J, Peterson, J, Priest, C, Li, S, Mishina, Y, Levi, B. mTOR inhibition and BMP signaling act synergistically to reduce muscle fibrosis and improve myofiber regeneration. JCI Insight. 2016;1 (20):e89805. doi: 10.1172/jci.insight.89805. PubMed PMID:27942591 PubMed Central PMC5135269.
Ranganathan, K, Agarwal, S, Cholok, D, Loder, S, Li, J, Sung Hsieh, HH, Wang, SC, Buchman, SR, Levi, B. The role of the adaptive immune system in burn-induced heterotopic ossification and mesenchymal cell osteogenic differentiation. J Surg Res. 2016;206 (1):53-61. doi: 10.1016/j.jss.2016.04.040. PubMed PMID:27916375 PubMed Central PMC5532013.
Agarwal, S, Loder, SJ, Cholok, D, Peterson, J, Li, J, Breuler, C, Cameron Brownley, R, Hsin Sung, H, Chung, MT, Kamiya, N, Li, S, Zhao, B, Kaartinen, V, Davis, TA, Qureshi, AT, Schipani, E, Mishina, Y, Levi, B. Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon. Stem Cells. 2017;35 (3):705-710. doi: 10.1002/stem.2515. PubMed PMID:27862618 PubMed Central PMC5529170.
Cholok, D, Lee, E, Lisiecki, J, Agarwal, S, Loder, S, Ranganathan, K, Qureshi, AT, Davis, TA, Levi, B. Traumatic muscle fibrosis: From pathway to prevention. J Trauma Acute Care Surg. 2017;82 (1):174-184. doi: 10.1097/TA.0000000000001290. PubMed PMID:27787441 PubMed Central PMC5177464.
Agarwal, S, Loder, S, Cholok, D, Peterson, J, Li, J, Fireman, D, Breuler, C, Hsieh, HS, Ranganathan, K, Hwang, C, Drake, J, Li, S, Chan, CK, Longaker, MT, Levi, B. Local and Circulating Endothelial Cells Undergo Endothelial to Mesenchymal Transition (EndMT) in Response to Musculoskeletal Injury. Sci Rep. 2016;6 :32514. doi: 10.1038/srep32514. PubMed PMID:27616463 PubMed Central PMC5018841.
Agarwal, S, Drake, J, Qureshi, AT, Loder, S, Li, S, Shigemori, K, Peterson, J, Cholok, D, Forsberg, JA, Mishina, Y, Davis, TA, Levi, B. Characterization of Cells Isolated from Genetic and Trauma-Induced Heterotopic Ossification. PLoS One. 2016;11 (8):e0156253. doi: 10.1371/journal.pone.0156253. PubMed PMID:27494521 PubMed Central PMC4975503.
Millet, JD, Brown, RK, Levi, B, Kraft, CT, Jacobson, JA, Gross, MD, Wong, KK. Frostbite: Spectrum of Imaging Findings and Guidelines for Management. Radiographics. 2016;36 (7):2154-2169. doi: 10.1148/rg.2016160045. PubMed PMID:27494386 PubMed Central PMC5131839.
Pavey, GJ, Qureshi, AT, Tomasino, AM, Honnold, CL, Bishop, DK, Agarwal, S, Loder, S, Levi, B, Pacifici, M, Iwamoto, M, Potter, BK, Davis, TA, Forsberg, JA. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016;90 :159-67. doi: 10.1016/j.bone.2016.06.014. PubMed PMID:27368930 PubMed Central PMC5546218.
Schneider, JC, Simko, LC, Goldstein, R, Shie, VL, Chernack, B, Levi, B, Jayakumar, P, Kowalske, KJ, Herndon, DN, Gibran, NS, Ryan, CM. Predicting Heterotopic Ossification Early After Burn Injuries: A Risk Scoring System. Ann Surg. 2017;266 (1):179-184. doi: 10.1097/SLA.0000000000001841. PubMed PMID:27348865 PubMed Central PMC9205532.
Kraft, C, Millet, JD, Agarwal, S, Wang, SC, Chung, KC, Brown, RK, Levi, B. SPECT/CT in the Evaluation of Frostbite. J Burn Care Res. 2017;38 (1):e227-e234. doi: 10.1097/BCR.0000000000000359. PubMed PMID:27306723 .
Hampel, JA, Rinkinen, J, Peterson, JR, Agarwal, S, Loder, S, Eboda, O, Enchakalody, B, Wang, SC, Buchman, SR, Levi, B. Early Development of the Mouse Morphome. J Craniofac Surg. 2016;27 (3):621-6. doi: 10.1097/SCS.0000000000002574. PubMed PMID:27100641 .
Agarwal, S, Loder, SJ, Sorkin, M, Li, S, Shrestha, S, Zhao, B, Mishina, Y, James, AW, Levi, B. Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification. Stem Cells. 2016;34 (6):1692-701. doi: 10.1002/stem.2376. PubMed PMID:27068890 PubMed Central PMC4892971.
Bayliss, JM, Levi, B, Wu, J, Wang, SC, Su, GL, Xi, C. Apyrase Elicits Host Antimicrobial Responses and Resolves Infection in Burns. J Burn Care Res. 2016;37 (6):e501-e507. doi: 10.1097/BCR.0000000000000335. PubMed PMID:27058579 PubMed Central PMC5086290.
Goverman, J, Kraft, CT, Fagan, S, Levi, B. Back Grafting the Split-Thickness Skin Graft Donor Site. J Burn Care Res. 2017;38 (1):e443-e449. doi: 10.1097/BCR.0000000000000314. PubMed PMID:27003740 PubMed Central PMC4879112.
Strong, AL, Hunter, RS, Jones, RB, Bowles, AC, Dutreil, MF, Gaupp, D, Hayes, DJ, Gimble, JM, Levi, B, McNulty, MA, Bunnell, BA. Obesity inhibits the osteogenic differentiation of human adipose-derived stem cells. J Transl Med. 2016;14 :27. doi: 10.1186/s12967-016-0776-1. PubMed PMID:26818763 PubMed Central PMC4730660.
Loder, S, Agarwal, S, Sorkin, M, Breuler, C, Li, J, Peterson, J, Gardenier, J, Hsieh, HH, Wang, SC, Mehrara, BJ, Levi, B. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264 (6):1174-1180. doi: 10.1097/SLA.0000000000001619. PubMed PMID:26779981 PubMed Central PMC4947025.
Walocko, FM, Khouri, RK Jr, Urbanchek, MG, Levi, B, Cederna, PS. The potential roles for adipose tissue in peripheral nerve regeneration. Microsurgery. 2016;36 (1):81-8. doi: 10.1002/micr.22480. PubMed PMID:26773850 PubMed Central PMC5089369.
Agarwal, S, Loder, S, Brownley, C, Cholok, D, Mangiavini, L, Li, J, Breuler, C, Sung, HH, Li, S, Ranganathan, K, Peterson, J, Tompkins, R, Herndon, D, Xiao, W, Jumlongras, D, Olsen, BR, Davis, TA, Mishina, Y, Schipani, E, Levi, B. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016;113 (3):E338-47. doi: 10.1073/pnas.1515397113. PubMed PMID:26721400 PubMed Central PMC4725488.
Mueller, N, Murthy, S, Tainter, CR, Lee, J, Riddell, K, Fintelmann, FJ, Grabitz, SD, Timm, FP, Levi, B, Kurth, T, Eikermann, M. Can Sarcopenia Quantified by Ultrasound of the Rectus Femoris Muscle Predict Adverse Outcome of Surgical Intensive Care Unit Patients as well as Frailty? A Prospective, Observational Cohort Study. Ann Surg. 2016;264 (6):1116-1124. doi: 10.1097/SLA.0000000000001546. PubMed PMID:26655919 PubMed Central PMC4907876.
Brownley, RC, Agarwal, S, Loder, S, Eboda, O, Li, J, Peterson, J, Hwang, C, Breuler, C, Kaartinen, V, Zhou, B, Mishina, Y, Levi, B. Characterization of Heterotopic Ossification Using Radiographic Imaging: Evidence for a Paradigm Shift. PLoS One. 2015;10 (11):e0141432. doi: 10.1371/journal.pone.0141432. PubMed PMID:26544555 PubMed Central PMC4636348.
Levi, B, Ibrahim, A, Mathews, K, Wojcik, B, Gomez, J, Fagan, S, Austen, WG Jr, Goverman, J. The Use of CO2 Fractional Photothermolysis for the Treatment of Burn Scars. J Burn Care Res. 2016;37 (2):106-14. doi: 10.1097/BCR.0000000000000285. PubMed PMID:26536539 .
Rinkinen, J, Hwang, CD, Agarwal, S, Oluwatobi, E, Peterson, J, Loder, S, Brownly, RC, Cummings, T, Cederna, PS, Levi, B. The Systemic Effect of Burn Injury and Trauma on Muscle and Bone Mass and Composition. Plast Reconstr Surg. 2015;136 (5):612e-623e. doi: 10.1097/PRS.0000000000001723. PubMed PMID:26505718 PubMed Central PMC4876821.
Levi, B, Jayakumar, P, Giladi, A, Jupiter, JB, Ring, DC, Kowalske, K, Gibran, NS, Herndon, D, Schneider, JC, Ryan, CM. Risk factors for the development of heterotopic ossification in seriously burned adults: A National Institute on Disability, Independent Living and Rehabilitation Research burn model system database analysis. J Trauma Acute Care Surg. 2015;79 (5):870-6. doi: 10.1097/TA.0000000000000838. PubMed PMID:26496115 PubMed Central PMC4621805.
Kraft, CT, Agarwal, S, Ranganathan, K, Wong, VW, Loder, S, Li, J, Delano, MJ, Levi, B. Trauma-induced heterotopic bone formation and the role of the immune system: A review. J Trauma Acute Care Surg. 2016;80 (1):156-65. doi: 10.1097/TA.0000000000000883. PubMed PMID:26491794 PubMed Central PMC4688132.
Agarwal, S, Loder, S, Li, J, Brownley, C, Peterson, JR, Oluwatobi, E, Drake, J, Cholok, D, Ranganathan, K, Sung, HH, Goulet, J, Li, S, Levi, B. Diminished Chondrogenesis and Enhanced Osteoclastogenesis in Leptin-Deficient Diabetic Mice (ob/ob) Impair Pathologic, Trauma-Induced Heterotopic Ossification. Stem Cells Dev. 2015;24 (24):2864-72. doi: 10.1089/scd.2015.0135. PubMed PMID:26413838 PubMed Central PMC4683546.
Peterson, JR, Agarwal, S, Loder, SJ, Eboda, O, Cederna, PS, Buchman, SR, Xi, C, Wang, SC, Levi, B. Picking a bone with heterotopic ossification: translational progress current and future. Ann Transl Med. 2015;3 (13):188. doi: 10.3978/j.issn.2305-5839.2015.07.27. PubMed PMID:26366405 PubMed Central PMC4543339.
Peterson, JR, Agarwal, S, Brownley, RC, Loder, SJ, Ranganathan, K, Cederna, PS, Mishina, Y, Wang, SC, Levi, B. Direct Mouse Trauma/Burn Model of Heterotopic Ossification. J Vis Exp. 2015; (102):e52880. doi: 10.3791/52880. PubMed PMID:26274052 PubMed Central PMC4544908.
Lloyd, WR, Agarwal, S, Nigwekar, SU, Esmonde-White, K, Loder, S, Fagan, S, Goverman, J, Olsen, BR, Jumlongras, D, Morris, MD, Levi, B. Raman spectroscopy for label-free identification of calciphylaxis. J Biomed Opt. 2015;20 (8):80501. doi: 10.1117/1.JBO.20.8.080501. PubMed PMID:26263412 PubMed Central PMC4689104.
Ranganathan, K, Loder, S, Agarwal, S, Wong, VW, Forsberg, J, Davis, TA, Wang, S, James, AW, Levi, B. Heterotopic Ossification: Basic-Science Principles and Clinical Correlates. J Bone Joint Surg Am. 2015;97 (13):1101-11. doi: 10.2106/JBJS.N.01056. PubMed PMID:26135077 PubMed Central PMC6948799.
Strong, AL, Cederna, PS, Rubin, JP, Coleman, SR, Levi, B. The Current State of Fat Grafting: A Review of Harvesting, Processing, and Injection Techniques. Plast Reconstr Surg. 2015;136 (4):897-912. doi: 10.1097/PRS.0000000000001590. PubMed PMID:26086386 PubMed Central PMC4833505.
Ranganathan, K, Peterson, J, Agarwal, S, Oluwatobi, E, Loder, S, Forsberg, JA, Davis, TA, Buchman, SR, Wang, SC, Levi, B. Role of gender in burn-induced heterotopic ossification and mesenchymal cell osteogenic differentiation. Plast Reconstr Surg. 2015;135 (6):1631-1641. doi: 10.1097/PRS.0000000000001266. PubMed PMID:26017598 PubMed Central PMC4448122.
Donneys, A, Blough, JT, Nelson, NS, Perosky, JE, Deshpande, SS, Kang, SY, Felice, PA, Figueredo, C, Peterson, JR, Kozloff, KM, Levi, B, Chepeha, DB, Buchman, SR. Translational treatment paradigm for managing non-unions secondary to radiation injury utilizing adipose derived stem cells and angiogenic therapy. Head Neck. 2016;38 Suppl 1 (Suppl 1):E837-43. doi: 10.1002/hed.24110. PubMed PMID:25917284 PubMed Central PMC4624054.
Agarwal, S, Loder, SJ, Brownley, C, Eboda, O, Peterson, JR, Hayano, S, Wu, B, Zhao, B, Kaartinen, V, Wong, VC, Mishina, Y, Levi, B. BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints. Dev Biol. 2015;400 (2):202-9. doi: 10.1016/j.ydbio.2015.02.011. PubMed PMID:25722188 PubMed Central PMC4397658.
Rinkinen, J, Lisiecki, J, Oluwatobi, E, Peterson, J, De La Rosa, S, Ranganathan, K, Wang, SC, Cederna, PS, Levi, B. Role of anatomical region and hypoxia on angiogenic markers in adipose-derived stromal cells. J Reconstr Microsurg. 2015;31 (2):132-8. doi: 10.1055/s-0034-1395494. PubMed PMID:25503422 .
Qureshi, AT, Doyle, A, Chen, C, Coulon, D, Dasa, V, Del Piero, F, Levi, B, Monroe, WT, Gimble, JM, Hayes, DJ. Photoactivated miR-148b-nanoparticle conjugates improve closure of critical size mouse calvarial defects. Acta Biomater. 2015;12 :166-173. doi: 10.1016/j.actbio.2014.10.010. PubMed PMID:25462528 PubMed Central PMC4397659.
Rinkinen, J, Agarwal, S, Beauregard, J, Aliu, O, Benedict, M, Buchman, SR, Wang, SC, Levi, B. Morphomic analysis as an aid for preoperative risk stratification in patients undergoing major head and neck cancer surgery. J Surg Res. 2015;194 (1):177-84. doi: 10.1016/j.jss.2014.10.002. PubMed PMID:25456114 PubMed Central PMC4823149.
Peterson, JR, De La Rosa, S, Eboda, O, Cilwa, KE, Agarwal, S, Buchman, SR, Cederna, PS, Xi, C, Morris, MD, Herndon, DN, Xiao, W, Tompkins, RG, Krebsbach, PH, Wang, SC, Levi, B. Treatment of heterotopic ossification through remote ATP hydrolysis. Sci Transl Med. 2014;6 (255):255ra132. doi: 10.1126/scitranslmed.3008810. PubMed PMID:25253675 PubMed Central PMC4353731.
Peterson, JR, Eboda, O, Agarwal, S, Ranganathan, K, Buchman, SR, Lee, M, Wang, SC, Mishina, Y, Levi, B. Targeting of ALK2, a Receptor for Bone Morphogenetic Proteins, Using the Cre/lox System to Enhance Osseous Regeneration by Adipose-Derived Stem Cells. Stem Cells Transl Med. 2014;3 (11):1375-80. doi: 10.5966/sctm.2014-0082. PubMed PMID:25232183 PubMed Central PMC4214843.
Lisiecki, J, Kozlow, JH, Agarwal, S, Ranganathan, K, Terjimanian, MN, Rinkinen, J, Brownley, RC, Enchakalody, B, Wang, SC, Levi, B. Abdominal wall dynamics after component separation hernia repair. J Surg Res. 2015;193 (1):497-503. doi: 10.1016/j.jss.2014.08.008. PubMed PMID:25201576 .
Loder, S, Peterson, JR, Agarwal, S, Eboda, O, Brownley, C, DeLaRosa, S, Ranganathan, K, Cederna, P, Wang, SC, Levi, B. Wound healing after thermal injury is improved by fat and adipose-derived stem cell isografts. J Burn Care Res. 2015;36 (1):70-6. doi: 10.1097/BCR.0000000000000160. PubMed PMID:25185931 PubMed Central PMC4286508.
Naghshineh, N, Brown, S, Cederna, PS, Levi, B, Lisiecki, J, D'Amico, RA, Hume, KM, Seward, W, Rubin, JP. Demystifying the U.S. Food and Drug Administration: understanding regulatory pathways. Plast Reconstr Surg. 2014;134 (3):559-569. doi: 10.1097/PRS.0000000000000477. PubMed PMID:25158712 .
Levi, B, Péault, B, James, AW. Bone tissue engineering and regeneration. Biomed Res Int. 2014;2014 :137529. doi: 10.1155/2014/137529. PubMed PMID:25136553 PubMed Central PMC4130199.
Peterson, JR, Eboda, ON, Brownley, RC, Cilwa, KE, Pratt, LE, De La Rosa, S, Agarwal, S, Buchman, SR, Cederna, PS, Morris, MD, Wang, SC, Levi, B. Effects of aging on osteogenic response and heterotopic ossification following burn injury in mice. Stem Cells Dev. 2015;24 (2):205-13. doi: 10.1089/scd.2014.0291. PubMed PMID:25122460 PubMed Central PMC4291203.
Perosky, JE, Peterson, JR, Eboda, ON, Morris, MD, Wang, SC, Levi, B, Kozloff, KM. Early detection of heterotopic ossification using near-infrared optical imaging reveals dynamic turnover and progression of mineralization following Achilles tenotomy and burn injury. J Orthop Res. 2014;32 (11):1416-23. doi: 10.1002/jor.22697. PubMed PMID:25087685 PubMed Central PMC4408934.
Tredget, EE, Levi, B, Donelan, MB. Biology and principles of scar management and burn reconstruction. Surg Clin North Am. 2014;94 (4):793-815. doi: 10.1016/j.suc.2014.05.005. PubMed PMID:25085089 PubMed Central PMC4286257.
Rinkinen, J, Selley, R, Agarwal, S, Loder, S, Levi, B. Skin allograft and vascularized composite allograft: potential for long-term efficacy in the context of lymphatic modulation. J Burn Care Res. 2014;35 (5):355-61. doi: 10.1097/BCR.0000000000000126. PubMed PMID:25051523 .
Kozlow, JH, Lisiecki, J, Terjimanian, MN, Rinkinen, J, Brownley, RC, Agarwal, S, Wang, SC, Levi, B. Cross-sectional area of the abdomen predicts complication incidence in patients undergoing sternal reconstruction. J Surg Res. 2014;192 (2):670-7. doi: 10.1016/j.jss.2014.05.041. PubMed PMID:24972736 PubMed Central PMC4631610.
Rinkinen, J, Wang, L, Zhang, P, Lisiecki, J, Enchakalody, B, Holcombe, S, Dombrowski, A, Wang, SC, Buchman, SR, Levi, B. Use of temporal morphomic indices as a clinically important variable in the diagnosis of nonsyndromic craniosynostosis. Ann Plast Surg. 2014;73 (1):86-91. doi: 10.1097/SAP.0b013e31826caf8d. PubMed PMID:24918738 .
Levi, B, Rinkinen, J, Kidwell, KM, Benedict, M, Stein, IC, Lisiecki, J, Enchakalody, B, Wang, SC, Kozlow, JH, Momoh, AO. Morphomic analysis for preoperative donor site risk assessment in patients undergoing abdominal perforator flap breast reconstruction: a proof of concept study. J Reconstr Microsurg. 2014;30 (9):635-40. doi: 10.1055/s-0034-1376400. PubMed PMID:24911410 .
Levi, B, Lisiecki, J, Rubin, P, D'Amico, RA, Hume, KM, Seward, B, Cederna, PS. Demystifying the U.S. Food and Drug Administration: I. Understanding agency structure and function. Plast Reconstr Surg. 2014;133 (6):1495-1501. doi: 10.1097/PRS.0000000000000215. PubMed PMID:24867731 .
Lisiecki, J, Rinkinen, J, Eboda, O, Peterson, J, De La Rosa, S, Agarwal, S, Dimick, J, Varban, OA, Cederna, PS, Wang, SC, Levi, B. Adipose-derived mesenchymal stem cells from ventral hernia repair patients demonstrate decreased vasculogenesis. Biomed Res Int. 2014;2014 :983715. doi: 10.1155/2014/983715. PubMed PMID:24757684 PubMed Central PMC3976822.
Levi, B, Zhang, P, Lisiecki, J, Terjimanian, MN, Rinkinen, J, Agarwal, S, Holcombe, SA, Kozlow, JH, Wang, SC, Kuzon, WM. Use of morphometric assessment of body composition to quantify risk of surgical-site infection in patients undergoing component separation ventral hernia repair. Plast Reconstr Surg. 2014;133 (4):559e-566e. doi: 10.1097/PRS.0000000000000009. PubMed PMID:24675208 .
Ma, LW, Levi, B, Oppenheimer, AJ, Kasten, SJ. Intralesional laser therapy for vascular malformations. Ann Plast Surg. 2014;73 (5):547-51. doi: 10.1097/SAP.0b013e318276daa6. PubMed PMID:24625513 .
Levi, B, Agarwal, S, Peterson, J, Oluwatobi, E, Ranganathan, K, Mishina, Y, Wang, SC, Buchman, SR, Cederna, PS. Abstract 148: use of bmp type I alk-3 knockout mice to develop novel treatment strategies for trauma-induced heterotopic ossification. Plast Reconstr Surg. 2014;133 (3 Suppl):162-163. doi: 10.1097/01.prs.0000444976.35528.b5. PubMed PMID:25942258 .
Ranganathan, K, Peterson, J, Eboda, O, Agarwal, S, Buchman, S, Cederna, P, Wang, S, Levi, B. Abstract 133: gender differences in heterotopic ossification. Plast Reconstr Surg. 2014;133 (3 Suppl):149. doi: 10.1097/01.prs.0000444960.44044.44. PubMed PMID:25942244 .
Rinkinen, J, Agarwal, S, Terjimanian, M, Beauregard, J, Ranganathan, K, Benedict, M, Hiltzik, D, Stein, I, Lisiecki, J, Wang, SC, Buchman, SR, Levi, B. Abstract 114: use of morphomic analysis for preoperative risk stratification in patients undergoing major head and neck cancer surgery. Plast Reconstr Surg. 2014;133 (3 Suppl):131. doi: 10.1097/01.prs.0000444939.16228.9f. PubMed PMID:25942225 .
Brownley, C, Agarwal, S, Peterson, J, Oluwatobi, E, Ranganathan, K, Wang, SC, Mishina, Y, Buchman, SR, Levi, B. Abstract 89: Novel Targeting of the Alk-2 Receptor Using the Cre/lox System to Enhance Osseous Regeneration by Mesenchymal Stem Cells. Plast Reconstr Surg. 2014;133 (3 Suppl):103. doi: 10.1097/01.prs.0000445122.92738.19. PubMed PMID:25942200 .
Agarwal, S, Peterson, J, De La Rosa, S, Ranganathan, K, Donneys, A, Wang, S, Cederna, PS, Buchman, SR, Levi, B. Abstract 35: central role of early vascularization in burn and trauma-induced heterotopic ossification. Plast Reconstr Surg. 2014;133 (3 Suppl):45-46. doi: 10.1097/01.prs.0000445068.55720.c0. PubMed PMID:25942146 .
Agarwal, S, Loder, S, Wood, S, Cederna, PS, Bishop, DK, Wang, SC, Levi, B. Engendering allograft ignorance in a mouse model of allogeneic skin transplantation to the distal hind limb. Ann Surg. 2015;261 (3):611-8. doi: 10.1097/SLA.0000000000000572. PubMed PMID:24509194 PubMed Central PMC4573553.
Chang, JB, Kung, TA, Levi, B, Irwin, T, Kadakia, A, Cederna, PS. Surgical management of burn flexion and extension contractures of the toes. J Burn Care Res. 2014;35 (1):93-101. doi: 10.1097/BCR.0b013e3182a368fc. PubMed PMID:24390110 .
Oppenheimer, AJ, Ranganathan, K, Levi, B, Strahle, JM, Kapurch, J, Muraszko, KM, Buchman, SR. Minimizing transfusions in primary cranial vault remodeling: the role of aminocaproic acid. J Craniofac Surg. 2014;25 (1):82-6. doi: 10.1097/SCS.0b013e3182a2e23f. PubMed PMID:24240766 .
Ranganathan, K, Terjimanian, M, Lisiecki, J, Rinkinen, J, Mukkamala, A, Brownley, C, Buchman, SR, Wang, SC, Levi, B. Temporalis muscle morphomics: the psoas of the craniofacial skeleton. J Surg Res. 2014;186 (1):246-52. doi: 10.1016/j.jss.2013.07.059. PubMed PMID:24079810 .
Lisiecki, J, Zhang, P, Wang, L, Rinkinen, J, De La Rosa, S, Enchakalody, B, Brownley, RC, Wang, SC, Buchman, SR, Levi, B. Morphomic measurement of the temporalis muscle and zygomatic bone as novel predictors of hospital-based clinical outcomes in patients with mandible fracture. J Craniofac Surg. 2013;24 (5):1577-81. doi: 10.1097/SCS.0b013e3182a12e02. PubMed PMID:24036730 .
Rinkinen, J, Terjimanian, M, Benedict, M, Hiltzik, D, Seyi, A, Lisiecki, J, Wang, SC, Buchman, SR, Levi, B. Temporal morphomics as a model for determining preoperative risk of blood transfusion in nonsyndromic craniosynostosis patients. Plast Reconstr Surg. 2013;132 (3):403e-412e. doi: 10.1097/PRS.0b013e31829ad31f. PubMed PMID:23985652 .
Levi, B, Glotzbach, JP, Sorkin, M, Hyun, J, Januszyk, M, Wan, DC, Li, S, Nelson, ER, Longaker, MT, Gurtner, GC. Molecular analysis and differentiation capacity of adipose-derived stem cells from lymphedema tissue. Plast Reconstr Surg. 2013;132 (3):580-589. doi: 10.1097/PRS.0b013e31829ace13. PubMed PMID:23985633 PubMed Central PMC4447496.
Deshpande, S, James, AW, Blough, J, Donneys, A, Wang, SC, Cederna, PS, Buchman, SR, Levi, B. Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation. J Surg Res. 2013;185 (1):278-85. doi: 10.1016/j.jss.2013.06.063. PubMed PMID:23972621 PubMed Central PMC4489542.
Bayliss, J, Delarosa, S, Wu, J, Peterson, JR, Eboda, ON, Su, GL, Hemmila, M, Krebsbach, PH, Cederna, PS, Wang, SC, Xi, C, Levi, B. Adenosine triphosphate hydrolysis reduces neutrophil infiltration and necrosis in partial-thickness scald burns in mice. J Burn Care Res. 2014;35 (1):54-61. doi: 10.1097/BCR.0b013e31829b36d6. PubMed PMID:23877144 PubMed Central PMC4152376.
Peterson, JR, De La Rosa, S, Sun, H, Eboda, O, Cilwa, KE, Donneys, A, Morris, M, Buchman, SR, Cederna, PS, Krebsbach, PH, Wang, SC, Levi, B. Burn injury enhances bone formation in heterotopic ossification model. Ann Surg. 2014;259 (5):993-8. doi: 10.1097/SLA.0b013e318291da85. PubMed PMID:23673767 PubMed Central PMC4498401.
Donneys, A, Ahsan, S, Perosky, JE, Deshpande, SS, Tchanque-Fossuo, CN, Levi, B, Kozloff, KM, Buchman, SR. Deferoxamine restores callus size, mineralization, and mechanical strength in fracture healing after radiotherapy. Plast Reconstr Surg. 2013;131 (5):711e-719e. doi: 10.1097/PRS.0b013e3182865c57. PubMed PMID:23629110 PubMed Central PMC3641519.
Donneys, A, Deshpande, SS, Tchanque-Fossuo, CN, Johnson, KL, Blough, JT, Perosky, JE, Kozloff, KM, Felice, PA, Nelson, NS, Farberg, AS, Levi, B, Buchman, SR. Deferoxamine expedites consolidation during mandibular distraction osteogenesis. Bone. 2013;55 (2):384-90. doi: 10.1016/j.bone.2013.04.005. PubMed PMID:23598047 PubMed Central PMC4162399.
Ranganathan, K, Wong, VW, Krebsbach, PH, Wang, SC, Cederna, PS, Levi, B. Fat grafting for thermal injury: current state and future directions. J Burn Care Res. 2013;34 (2):219-26. doi: 10.1097/BCR.0b013e318280e2dd. PubMed PMID:23370993 .
Rinkinen, J, Zhang, P, Wang, L, Enchakalody, B, Terjimanian, M, Holcomb, S, Wang, SC, Buchman, SR, Levi, B. Novel temporalis muscle and fat pad morphomic analyses aids preoperative risk evaluation and outcome assessment in nonsyndromic craniosynostosis. J Craniofac Surg. 2013;24 (1):250-5. doi: 10.1097/SCS.0b013e31827006f5. PubMed PMID:23348295 .
Lisiecki, J, Wan, DC, Wang, L, Zhang, P, Enchakalody, B, Zhang, X, Kasten, SJ, Wang, SC, Buchman, SR, Levi, B. Novel application of human morphomics to quantify temporal soft tissues in Pierre Robin and Treacher Collins. J Craniofac Surg. 2013;24 (1):158-62. doi: 10.1097/SCS.0b013e3182646411. PubMed PMID:23348276 .
Peterson, JR, Okagbare, PI, De La Rosa, S, Cilwa, KE, Perosky, JE, Eboda, ON, Donneys, A, Su, GL, Buchman, SR, Cederna, PS, Wang, SC, Kozloff, KM, Morris, MD, Levi, B. Early detection of burn induced heterotopic ossification using transcutaneous Raman spectroscopy. Bone. 2013;54 (1):28-34. doi: 10.1016/j.bone.2013.01.002. PubMed PMID:23314070 PubMed Central PMC3690323.
Chung, MT, Levi, B, Hyun, JS, Lo, DD, Montoro, DT, Lisiecki, J, Bradley, JP, Buchman, SR, Longaker, MT, Wan, DC. Pierre Robin sequence and Treacher Collins hypoplastic mandible comparison using three-dimensional morphometric analysis. J Craniofac Surg. 2012;23 (7 Suppl 1):1959-63. doi: 10.1097/SCS.0b013e318258bcf1. PubMed PMID:23154353 PubMed Central PMC3544559.
Levi, B, Hyun, JS, Montoro, DT, Lo, DD, Chan, CK, Hu, S, Sun, N, Lee, M, Grova, M, Connolly, AJ, Wu, JC, Gurtner, GC, Weissman, IL, Wan, DC, Longaker, MT. In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc Natl Acad Sci U S A. 2012;109 (50):20379-84. doi: 10.1073/pnas.1218052109. PubMed PMID:23169671 PubMed Central PMC3528603.
Donneys, A, Weiss, DM, Deshpande, SS, Ahsan, S, Tchanque-Fossuo, CN, Sarhaddi, D, Levi, B, Goldstein, SA, Buchman, SR. Localized deferoxamine injection augments vascularity and improves bony union in pathologic fracture healing after radiotherapy. Bone. 2013;52 (1):318-25. doi: 10.1016/j.bone.2012.10.014. PubMed PMID:23085084 PubMed Central PMC3513581.
Chung, MT, Hyun, JS, Lo, DD, Montoro, DT, Hasegawa, M, Levi, B, Januszyk, M, Longaker, MT, Wan, DC. Micro-computed tomography evaluation of human fat grafts in nude mice. Tissue Eng Part C Methods. 2013;19 (3):227-32. doi: 10.1089/ten.TEC.2012.0371. PubMed PMID:22916732 PubMed Central PMC3557441.
Wong, VW, Levi, B, Rajadas, J, Longaker, MT, Gurtner, GC. Stem cell niches for skin regeneration. Int J Biomater. 2012;2012 :926059. doi: 10.1155/2012/926059. PubMed PMID:22701121 PubMed Central PMC3371691.
Nelson, ER, Wong, VW, Krebsbach, PH, Wang, SC, Levi, B. Heterotopic ossification following burn injury: the role of stem cells. J Burn Care Res. 2012;33 (4):463-70. doi: 10.1097/BCR.0b013e31825af547. PubMed PMID:22683987 .
Levi, B, Glotzbach, JP, Wong, VW, Nelson, ER, Hyun, J, Wan, DC, Gurtner, GC, Longaker, MT. Stem cells: update and impact on craniofacial surgery. J Craniofac Surg. 2012;23 (1):319-22. doi: 10.1097/SCS.0b013e318241dbaf. PubMed PMID:22337434 PubMed Central PMC3282019.
Levi, B, Wan, DC, Wong, VW, Nelson, E, Hyun, J, Longaker, MT. Cranial suture biology: from pathways to patient care. J Craniofac Surg. 2012;23 (1):13-9. doi: 10.1097/SCS.0b013e318240c6c0. PubMed PMID:22337368 .
Scott, MA, Levi, B, Askarinam, A, Nguyen, A, Rackohn, T, Ting, K, Soo, C, James, AW. Brief review of models of ectopic bone formation. Stem Cells Dev. 2012;21 (5):655-67. doi: 10.1089/scd.2011.0517. PubMed PMID:22085228 PubMed Central PMC3295855.
Nelson, ER, Levi, B, Sorkin, M, James, AW, Liu, KJ, Quarto, N, Longaker, MT. Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme. PLoS One. 2011;6 (10):e25847. doi: 10.1371/journal.pone.0025847. PubMed PMID:22022457 PubMed Central PMC3194817.
Levi, B, Hyun, JS, Nelson, ER, Li, S, Montoro, DT, Wan, DC, Jia, FJ, Glotzbach, JC, James, AW, Lee, M, Huang, M, Quarto, N, Gurtner, GC, Wu, JC, Longaker, MT. Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair. Stem Cells. 2011;29 (12):2018-29. doi: 10.1002/stem.757. PubMed PMID:21997852 PubMed Central PMC4353732.
Levi, B, Brugman, S, Wong, VW, Grova, M, Longaker, MT, Wan, DC. Palatogenesis: engineering, pathways and pathologies. Organogenesis. 2011;7 (4):242-54. doi: 10.4161/org.7.4.17926. PubMed PMID:21964245 PubMed Central PMC3265826.
Nelson, ER, Levi, B, Longaker, MT. Commentary on role of apoptosis in retinoic Acid-induced cleft palate. J Craniofac Surg. 2011;22 (5):1572-3. doi: 10.1097/SCS.0b013e31822e5ea6. PubMed PMID:21959389 .
Levi, B, Wan, DC, Glotzbach, JP, Hyun, J, Januszyk, M, Montoro, D, Sorkin, M, James, AW, Nelson, ER, Li, S, Quarto, N, Lee, M, Gurtner, GC, Longaker, MT. CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor β1 (TGF-β1) signaling. J Biol Chem. 2011;286 (45):39497-509. doi: 10.1074/jbc.M111.256529. PubMed PMID:21949130 PubMed Central PMC3234773.
Tsao, CK, Wan, DC, Chen, WF, Kao, DS, Levi, B. The commissure-based triangular flap for lip revision following reconstruction of a through-and-through defect. J Plast Reconstr Aesthet Surg. 2012;65 (2):271-3. doi: 10.1016/j.bjps.2011.08.007. PubMed PMID:21945062 .
Levi, B, Sugg, KB, Lien, SC, Kasten, SJ, Muraszko, KM, Maher, CO, Buchman, SR. Outcomes of tethered cord repair with a layered soft tissue closure. Ann Plast Surg. 2013;70 (1):74-8. doi: 10.1097/SAP.0b013e31822f9ada. PubMed PMID:21921789 .
Levi, B, Nelson, ER, Hyun, JS, Glotzbach, JP, Li, S, Nauta, A, Montoro, DT, Lee, M, Commons, GC, Hu, S, Wu, JC, Gurtner, GC, Longaker, MT. Enhancement of human adipose-derived stromal cell angiogenesis through knockdown of a BMP-2 inhibitor. Plast Reconstr Surg. 2012;129 (1):53-66. doi: 10.1097/PRS.0b013e3182361ff5. PubMed PMID:21915082 PubMed Central PMC3246067.
Levi, B, Nelson, ER, Brown, K, James, AW, Xu, D, Dunlevie, R, Wu, JC, Lee, M, Wu, B, Commons, GW, Vistnes, D, Longaker, MT. Differences in osteogenic differentiation of adipose-derived stromal cells from murine, canine, and human sources in vitro and in vivo. Plast Reconstr Surg. 2011;128 (2):373-386. doi: 10.1097/PRS.0b013e31821e6e49. PubMed PMID:21788829 PubMed Central PMC5764702.
Lee, AS, Xu, D, Plews, JR, Nguyen, PK, Nag, D, Lyons, JK, Han, L, Hu, S, Lan, F, Liu, J, Huang, M, Narsinh, KH, Long, CT, de Almeida, PE, Levi, B, Kooreman, N, Bangs, C, Pacharinsak, C, Ikeno, F, Yeung, AC, Gambhir, SS, Robbins, RC, Longaker, MT, Wu, JC. Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells. J Biol Chem. 2011;286 (37):32697-704. doi: 10.1074/jbc.M111.235739. PubMed PMID:21719696 PubMed Central PMC3173214.
Levi, B, Nelson, ER, Li, S, James, AW, Hyun, JS, Montoro, DT, Lee, M, Glotzbach, JP, Commons, GW, Longaker, MT. Dura mater stimulates human adipose-derived stromal cells to undergo bone formation in mouse calvarial defects. Stem Cells. 2011;29 (8):1241-55. doi: 10.1002/stem.670. PubMed PMID:21656608 PubMed Central PMC4353733.
Scott, MA, Nguyen, VT, Levi, B, James, AW. Current methods of adipogenic differentiation of mesenchymal stem cells. Stem Cells Dev. 2011;20 (10):1793-804. doi: 10.1089/scd.2011.0040. PubMed PMID:21526925 PubMed Central PMC3182038.
Levi, B, Longaker, MT. Osteogenic differentiation of adipose-derived stromal cells in mouse and human: in vitro and in vivo methods. J Craniofac Surg. 2011;22 (2):388-91. doi: 10.1097/SCS.0b013e318207b72b. PubMed PMID:21415625 .
Levi, B, Longaker, MT. Research training in plastic surgery. J Craniofac Surg. 2011;22 (2):383-4. doi: 10.1097/SCS.0b013e318208ba73. PubMed PMID:21415623 .
Levi, B, James, AW, Nelson, ER, Brugmann, SA, Sorkin, M, Manu, A, Longaker, MT. Role of Indian hedgehog signaling in palatal osteogenesis. Plast Reconstr Surg. 2011;127 (3):1182-1190. doi: 10.1097/PRS.0b013e3182043a07. PubMed PMID:21364421 PubMed Central PMC3078688.
Levi, B, James, AW, Nelson, ER, Hu, S, Sun, N, Peng, M, Wu, J, Longaker, MT. Studies in adipose-derived stromal cells: migration and participation in repair of cranial injury after systemic injection. Plast Reconstr Surg. 2011;127 (3):1130-1140. doi: 10.1097/PRS.0b013e3182043712. PubMed PMID:21364416 PubMed Central PMC3248272.
Levi, B, James, AW, Nelson, ER, Peng, M, Wan, DC, Commons, GW, Lee, M, Wu, B, Longaker, MT. Acute skeletal injury is necessary for human adipose-derived stromal cell-mediated calvarial regeneration. Plast Reconstr Surg. 2011;127 (3):1118-1129. doi: 10.1097/PRS.0b013e318205f274. PubMed PMID:21364415 PubMed Central PMC3073240.
Levi, B, Longaker, MT. Concise review: adipose-derived stromal cells for skeletal regenerative medicine. Stem Cells. 2011;29 (4):576-82. doi: 10.1002/stem.612. PubMed PMID:21305671 PubMed Central PMC3323288.
Levi, B, Wan, DC, Longaker, MT, Habal, MB. Deformational plagiocephaly: a look into the future. J Craniofac Surg. 2011;22 (1):3-5. doi: 10.1097/SCS.0b013e3181fb7ee5. PubMed PMID:21239916 .
Rustad, KC, Sorkin, M, Levi, B, Longaker, MT, Gurtner, GC. Strategies for organ level tissue engineering. Organogenesis. 2010;6 (3):151-7. doi: 10.4161/org.6.3.12139. PubMed PMID:21197216 PubMed Central PMC2946046.
Brown, SA, Levi, B, Lequex, C, Wong, VW, Mojallal, A, Longaker, MT. Basic science review on adipose tissue for clinicians. Plast Reconstr Surg. 2010;126 (6):1936-1946. doi: 10.1097/PRS.0b013e3181f44790. PubMed PMID:21124133 .
Glotzbach, JP, Levi, B, Wong, VW, Longaker, MT, Gurtner, GC. The basic science of vascular biology: implications for the practicing surgeon. Plast Reconstr Surg. 2010;126 (5):1528-1538. doi: 10.1097/PRS.0b013e3181ef8ccf. PubMed PMID:21042110 .
Wan, DC, Gabbay, J, Levi, B, Boyd, JB, Granzow, JW. Quality of innervation in sensate medial plantar flaps for heel reconstruction. Plast Reconstr Surg. 2011;127 (2):723-730. doi: 10.1097/PRS.0b013e3181fed76d. PubMed PMID:20966816 .
Levi, B, Brugmann, S, Longaker, MT. Discussion: Hes1 is required for the development of craniofacial structures derived from ectomesenchymal neural crest cells. J Craniofac Surg. 2010;21 (5):1450-1. doi: 10.1097/SCS.0b013e3181ecc54b. PubMed PMID:20818250 .
Levi, B, James, AW, Glotzbach, JP, Wan, DC, Commons, GW, Longaker, MT. Depot-specific variation in the osteogenic and adipogenic potential of human adipose-derived stromal cells. Plast Reconstr Surg. 2010;126 (3):822-834. doi: 10.1097/PRS.0b013e3181e5f892. PubMed PMID:20811215 .
James, AW, Levi, B, Commons, GW, Glotzbach, J, Longaker, MT. Paracrine interaction between adipose-derived stromal cells and cranial suture-derived mesenchymal cells. Plast Reconstr Surg. 2010;126 (3):806-821. doi: 10.1097/PRS.0b013e3181e5f81a. PubMed PMID:20811214 PubMed Central PMC2933932.
Levi, B, James, AW, Nelson, ER, Li, S, Peng, M, Commons, GW, Lee, M, Wu, B, Longaker, MT. Human adipose-derived stromal cells stimulate autogenous skeletal repair via paracrine Hedgehog signaling with calvarial osteoblasts. Stem Cells Dev. 2011;20 (2):243-57. doi: 10.1089/scd.2010.0250. PubMed PMID:20698749 PubMed Central PMC3128781.
Levi, B, James, AW, Xu, Y, Commons, GW, Longaker, MT. Divergent modulation of adipose-derived stromal cell differentiation by TGF-beta1 based on species of derivation. Plast Reconstr Surg. 2010;126 (2):412-425. doi: 10.1097/PRS.0b013e3181df64dc. PubMed PMID:20679827 .
Lee, J, Gupta, D, Panetta, NJ, Levi, B, James, AW, Wan, D, Commons, GW, Longaker, MT. Elucidating mechanisms of osteogenesis in human adipose-derived stromal cells via microarray analysis. J Craniofac Surg. 2010;21 (4):1136-41. doi: 10.1097/SCS.0b013e3181e488d6. PubMed PMID:20613589 .
Levi, B, Ko, SH, Longaker, MT. Commentary. Aesthet Surg J. 2010;30 (3):387-9. doi: 10.1177/1090820X10374102. PubMed PMID:20601561 .
Levi, B, James, AW, Nelson, ER, Vistnes, D, Wu, B, Lee, M, Gupta, A, Longaker, MT. Human adipose derived stromal cells heal critical size mouse calvarial defects. PLoS One. 2010;5 (6):e11177. doi: 10.1371/journal.pone.0011177. PubMed PMID:20567510 PubMed Central PMC2887361.
James, AW, Levi, B, Nelson, ER, Peng, M, Commons, GW, Lee, M, Wu, B, Longaker, MT. Deleterious effects of freezing on osteogenic differentiation of human adipose-derived stromal cells in vitro and in vivo. Stem Cells Dev. 2011;20 (3):427-39. doi: 10.1089/scd.2010.0082. PubMed PMID:20536327 PubMed Central PMC3128779.
James, AW, Leucht, P, Levi, B, Carre, AL, Xu, Y, Helms, JA, Longaker, MT. Sonic Hedgehog influences the balance of osteogenesis and adipogenesis in mouse adipose-derived stromal cells. Tissue Eng Part A. 2010;16 (8):2605-16. doi: 10.1089/ten.TEA.2010.0048. PubMed PMID:20367246 PubMed Central PMC2947454.
Levi, B, James, AW, Wan, DC, Glotzbach, JP, Commons, GW, Longaker, MT. Regulation of human adipose-derived stromal cell osteogenic differentiation by insulin-like growth factor-1 and platelet-derived growth factor-alpha. Plast Reconstr Surg. 2010;126 (1):41-52. doi: 10.1097/PRS.0b013e3181da8858. PubMed PMID:20220555 PubMed Central PMC3016898.
Levi, B, Kasten, SJ, Buchman, SR. Use of cross-bone strut stabilization for barrel stave osteotomies in calvarial reconstruction. J Craniofac Surg. 2010;21 (2):491-4. doi: 10.1097/SCS.0b013e3181cfecf3. PubMed PMID:20216448 .
James, AW, Levi, B, Xu, Y, Carre, AL, Longaker, MT. Retinoic acid enhances osteogenesis in cranial suture-derived mesenchymal cells: potential mechanisms of retinoid-induced craniosynostosis. Plast Reconstr Surg. 2010;125 (5):1352-1361. doi: 10.1097/PRS.0b013e3181d62980. PubMed PMID:20134361 PubMed Central PMC2909493.
Kasten, SJ, Levi, B, Eng, D, Schenarts, KA. Toward outcomes-based plastic surgery training: a needs assessment of recent graduates. Plast Reconstr Surg. 2009;124 (5):1703-1710. doi: 10.1097/PRS.0b013e3181b98c49. PubMed PMID:20009859 .
Levi, B, Brown, DL, Cederna, PS. A comparative analysis of tissue expander reconstruction of burned and unburned chest and breasts using endoscopic and open techniques. Plast Reconstr Surg. 2010;125 (2):547-556. doi: 10.1097/PRS.0b013e3181c91d27. PubMed PMID:19910841 .
Levi, B, Clevenger, L, Williams, BC, Kasten, SJ. Residents' views of plastic surgery in the geriatric population: an objective needs assessment for graduate plastic surgery education. Ann Plast Surg. 2009;63 (3):314-7. doi: 10.1097/SAP.0b013e31818d14d1. PubMed PMID:19602947 .
Levi, B, Kasten, SJ, Buchman, SR. Utilization of the buccal fat pad flap for congenital cleft palate repair. Plast Reconstr Surg. 2009;123 (3):1018-1021. doi: 10.1097/PRS.0b013e318199f80f. PubMed PMID:19319069 .
Levi, B, Rademaker, AW, Fine, NA, Mustoe, TA. Comparison of breast implant deflation for mentor anterior and posterior valve designs in aesthetic and reconstructive patients. Plast Reconstr Surg. 2008;122 (3):685-692. doi: 10.1097/PRS.0b013e318182378e. PubMed PMID:18766029 .
Levi, B, Rees, R. Diagnosis and management of pressure ulcers. Clin Plast Surg. 2007;34 (4):735-48. doi: 10.1016/j.cps.2007.07.007. PubMed PMID:17967627 .

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Editor, Michigan Manual of Plastic Surgery, Second Edition. (Lippincott Williams and Wilkins, New York, in progress).

Section Editor, “Burns.” Michigan Manual of Plastic Surgery, Second Edition. (Lippincott Williams and Wilkins, New York, in progress).

Section Editor, “Trunk and Lower Extremity Reconstruction” Michigan Manual of Plastic Surgery, Second Edition. (Lippincott Williams and Wilkins, New York, in progress).

Section Editor, “Fundamentals and Principles.” Michigan Manual of Plastic Surgery, Second Edition. (Lippincott Williams and Wilkins, New York, in progress)

Chapter: Levi B, Wong VC and Sheridan R. Burn Surgery and Critical Care. Massachussetts General Hospital Critical Care Handbook, Ed. 2. In Press.
Chapter: Levi B, Hemilla M, and Wang SC. Burn Surgery. Greenfield’s Surgery Ed 8. In Press.
Chapter: Donneys A, Nelson N, Ahsan S, Peterson JR, Morris MD, Esmonde-White F, Buchman SR, Wang SC, and Levi B. “Advancements in Cortical Bone Imaging”Trabecular and Cortical Bone: Morphology, Biomechanics and Clinical Implications. Ed Varsha Subramanium and Manish Bhatnagar. New York: Nova Biomedical, 2014. 137-162.
Review: JP Glotzbach, VW Wong, Levi B, MT Longaker, GC Gurtner. Delivery
Review: Strong AL, Ranganathan K, Chang ET, Sorkin M, Agarwal S and Levi B. Burns: Epidemiology, Management and Impact on Muscle & Joint Function. Accepted for publication 12/2013.
Review: Glotzbach JG*, Levi B*, Wong V, Longaker MT and Gurtner GC. The Basic Science of Vascular Biology: Implications for the Practicing Surgeon. Plast. Reconstr. Surg. 126(5):1528-38, 2010. PMID: 21042110.

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First annual CORT Scientific Retreat

May 2, 2024

The first Center for Organogenesis, Regeneration and Trauma (CORT) Scientific Retreat was hosted on Friday, March 1st, 2024, on the University of Texas Southwestern Medical Center campus. Attendance was nearly standing room only with plenaries by speakers from...

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